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American Society of Microbiology ABMM Sample Questions:

1. A patient with a history of travel to Southeast Asia presents with fever, severe headache, and altered mental status. CSF analysis reveals lymphocytic pleocytosis and elevated protein, but routine bacterial and viral cultures are negative. Serological testing of CSF is positive for IgM antibodies against Japanese encephalitis virus. The MOST likely mode of transmission for this infection is:

A) Respiratory droplets from an infected individual.
B) Bite of an infected mosquito.
C) Direct contact with infected animals.
D) Ingestion of contaminated food or water.

2. A patient presents with a chronic cough, weight loss, and night sweats. Chest X-ray shows cavitarylesions in the upper lobes. Sputum is acid-fast positive. Drug susceptibility testing reveals resistance to isoniazid but susceptibility to rifampin, ethambutol, and pyrazinamide. The MOST appropriate treatment regimen should include:

A) Isoniazid, ethambutol, and pyrazinamide
B) Rifampin, ethambutol, and pyrazinamide
C) Isoniazid, rifampin, pyrazinamide, and ethambutol
D) Isoniazid and rifampin

3. Acyclovir is a commonly used antiviral agent effective against Herpes Simplex Virus (HSV) and Varicella- Zoster Virus (VZV). Its selective toxicity relies on which initial step for activation within infected cells?

A) Blocking viral entry through competitive inhibition of cellular receptors
B) Phosphorylation by host cell mitochondrial kinases
C) Monophosphorylation primarily by viral thymidine kinase
D) Direct inhibition of viral RNA polymerase activity

4. A patient with a history of chronic sinusitis develops a severe invasive fungal infection involving the nasal sinuses and extending into the orbit. Tissue biopsy reveals broad, aseptate hyphae with irregular branching.
The patient is diabetic and acidotic. The MOST likely causative organism belongs to the genus:

A) Mucor or Rhizopus
B) Scedosporium
C) Fusarium
D) Aspergillus

5. A clinical microbiology laboratory is implementing a new quality control procedure for blood culture media.
To ensure the media supports the growth of a wide range of clinically significant organisms, they should include:

A) Only control strains that are commonly found as contaminants.
B) Only Gram-positive and Gram-negative control strains.
C) Only antibiotic-resistant control strains.
D) A diverse panel of fastidious and non-fastidious bacteria and yeasts.

Solutions: